In a large mixing bowl, combine ground beef, ground pork, breadcrumbs, eggs, garlic powder, onion powder, salt, and pepper. Mix thoroughly for about 3-4 minutes until well incorporated.

In a separate bowl, blend the softened cream cheese, shredded cheddar cheese, diced jalapeños, and cilantro until smooth and creamy, about 2-3 minutes.

Preheat your oven to 350°F (175°C). Grease a loaf pan and press half of the meat mixture into the bottom. Create a well in the center for the filling.

Spoon the filling into the well, spread evenly, and top with the remaining meat mixture, sealing the filling completely.

Bake for approximately 1 hour, checking that the internal temperature reaches 160°F (71°C). The top should be golden brown.

Remove from the oven and let rest for about 10 minutes before slicing and serving warm.